Figure 1 : In-silico predicted normalized intensity of the immune response (y-axis) induced through different hypothetical vaccination schedules in which the delay (l), in days, between the first dose and the second dose administration was considered to be variable (x-axis).
Olivera-Botello G, Jacquard AC, Gueyffier F, Soubeyrand B BJ. Mathematical modeling of the immune responses induced by HPV vaccination. Computational Mathematical Methods in Medicine 2012; submitted article.
It has been previously suggested that by reducing the intervals between the vaccine doses there is a considerable risk of falling into a zone of sub-optimal immunogenic performance. Some evidence on this was published more than 20 years ago in the form of a study (1) on the hepatitis-B vaccine. Our findings support this empirical result (Figure1).
The model was first calibrated and then validated on the basis of real data taken from literature regarding the induction of immune memory (Figure 3).
1. Jilg W, Schmidt M, Deinhardt F. Vaccination against Hepatitis B: Comparison of Three Different Vaccination Schedules. The Journal of Infectious Diseases 1989;160(5):766-9