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nova
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Publication date: May 12, 2022
nova's story
#History
#Novadiscovery
Back in the 1990s, the idea of running computer-simulated clinical trials would have seemed far-fetched. The internet had only just emerged, personal computers were the size of suitcases, and...
3 min read
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Publication date: May 12, 2022
What are in silico trials? What is jinkō?
#clinical trials
#jinkō
In silico trials are computer-based simulations of how a drug or disease impacts physiological and clinical outcomes.
2 min read
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Publication date: Jan 18, 2023
Getting the dose right - the FDA's project optimus changes the dose-finding paradigm in oncology
#clinical trials
#Drug development
#in silico
#jinkō
#Oncology
#Project Optimus
Personalized medicine is more than matching a drug to an individual. It also means getting the dose right. Using the jinkō platform, developers can precisely simulate a therapy’s effects..
2 min read
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Publication date: Dec 12, 2022
FDA wants trials to include obese patients. Modeling will help
#clinical trials
#Drug development
#in silico
#Modeling
#obese patients
On November 9, FDA held a workshop to explore whether obese patients should be included in drug trials. If so, drug development costs and timelines would rocket...
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Publication date: Nov 09, 2022
From Digital Twins to Digital Cohorts
#clinical trials
#digital twin
#in silico
What is a digital twin? At its most general, it’s a virtual copy of a physical object (jet engine), organism (person, animal) or process (circulation, drug metabolism), used for running simulations.
2 min read
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Publication date: Oct 17, 2022
In silico trials can reduce animal testing
#Animal testing
#clinical trials
#in silico
#R&D
In silico modeling is emerging as an important partial alternative to animal testing. It is likely to be better at predicting efficacy and toxicity in humans...
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Publication date: Sep 12, 2022
Managing knowledge to accelerate R&D
#clinical trials
#Knowledge
#R&D
Curated knowledge repositories allow R&D experts to systematically capture validated information avoid flaky data or irrelevant claims, and remain alert to new developments.
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Publication date: Mar 14, 2022
How in silico can help HTA
#clinical trials
#HTA
#in silico
Faster drug approvals based on less evidence mean new tools are needed to track cost-effectiveness. As regulators approve more drugs faster , health technology assessors are under growing pressure...
3 min read
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Publication date: Feb 14, 2022
A standout 2021 supports in silico trials
#clinical trials
#in silico
Systems and minds opened up , adjusting to a world beyond conventional trials. That world should, and increasingly does, include in silico trials .
1 min read
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Publication date: Jan 25, 2022 - Giulio Foresto
Scoring data quality builds trust in in silico modeling
#data
#scoring
More data, by itself, does not guarantee better results or more accurate predictions from in silico modeling. Those depend on the quality and completeness of source data, the accuracy of the...
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Publication date: Dec 01, 2021
The power of synthetic control arms
#control arms
#RWD
Control arms are key to reliably determining whether a new treatment works better than what already exists. The data they generate – from trial patients who receive a placebo, the standard of...
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