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New insights on the relation between untreated and treated outcomes for a given therapy

Boissel JP, Cucherat M, Nony P, Chabaud S, Gueyffier F, Wright JM, Lièvre M, Leizorovicz,
J Clin Epidemio 2008; 61:301-7

Abstract

A relation between the size of treatment efficacy and severity of the disease has been postulated and observed as linear for a few therapies. We have called this relation the effect model. Contrarily to common, assumption, since the effect model is often curvilinear, the relative risk cannot be granted as constant. The effect model should be taken into account when discovering and developing new therapies, when making, health care policy decisions or adjusting clinical decisions to the patient risk profile.