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Prediction of chronic lung allograft dysfunction: a systems medicine challenge

Pison C, Magnan A, Botturi K, Sève M, Brouard S, Marsland BJ, Ernst F, Paprotka T, Deplanche K, Fritz A, Siroux V, Boissel JP, Corris PA, Auffray C, Nicod LP; SysCLAD consortium,
Eur Respir J. 2014 Mar;43(3):689-93

Abstract

In an attempt to better predict CLAD before irreversible damage occurs within the graft, a multidisciplinary consortium Systems prediction of CLAD (SysCLAD) was set up with 14 lung transplantations centres, four small and medium enterprises, and three academic platforms and was funded by the European Union under the Seventh Framework Programme. The objective of SysCLAD is to build a computational model in order to estimate, within the first year post-LT, a personal recipient risk of CLAD at 3 years, a timeframe associated with the worst vital prognosis.